Today, Healthsoothe brings to you another article. This article is on a drug known as the 4H2 pill, which is a medication used to treat allergies. 

Quick Facts About 4H2 Pill

Name4H2 Pill
ManufacturerPerrigo Company
Active IngredientsCetirizine Hydrochloride and Prednisolone sodium phosphate
Type of MedicationAntihistamine
Controlled Substance ClassificationNot a controlled substance
Uses Treats allergic rhinitis, urticaria, and other allergy symptoms
Dosage Usually once a day, can be twice depending on severity
Dosage Form Tablet
Side Effects Headaches, stomach pain, dizziness, dry mouth, etc.
InteractionsAvoid alcohol, may interact with other sedatives
Pregnancy Category B – No proven risk in humans
Availability  Generally available over-the-counter (OTC)
Cost• 10,910 NGN - 39,550 NGN per pack

• 7.92 GBP - 39.62 GBP per pack

• 10.00 USD - 50.00 USD per pack

• 9.28 EUR - 46.40 EUR per pack

• 70.61 CNY - 353.04 CNY per pack

Are you suffering from a bee sting, hive, or other certain allergies, and you are wondering whether the 4H2 pill can solve your allergy problem? Ten don’t worry, we have got you covered here. 

Or have this medicine been recommended to you to treat a friend’s allergy, a family member’s allergy, or your allergy, and you wanna find out whether this medicine is safe, how it works, its dosage, uses, side effects, and precautions? 

Well, no need to go further, this article will answer all the questions you have on the 4H2 pill and more, including info on what kind of allergies the 4H2 pill can efficiently treat and alternative medications for 4H2 if you discovered that 4H2 won’t do it for you on reading through this article.

Alright then, enough intro. Now, let’s delve in.


4H2 pill - What is it?

4H2 Pill - Healthsoothe

4H2 pill is a white, oval/elliptical pill or medicine which has been identified as Cetirizine Hydrochloride (mainly called Cetirizine). It belongs to the antihistamine drug class.

4H2 pill is a 2nd-generation antihistamine that reduces the body's natural chemical histamine. Histamines can cause sneezing, itching, watery eyes, and a runny nose.

Perrigo Company produces and supplies 4H2 pills. 4H2 is derived from its molecular name, 4-methylpyridine-2(1H)-thione.

4H2 pill is mostly used to treat allergies and other related conditions.

4H2 drug details summary

  • Imprint: 4H2.
  • Strength:10 mg.
  • Color: White.
  • Size: 10.00 mm.
  • Shape: Elliptical/Oval.
  • Availability: Rx and/or OTC.
  • Drug Class: Antihistamines.
  • Pregnancy Category: B - No proven risk in humans.
  • CSA Schedule: Not a controlled drug.
  • Labeler / Supplier: Perrigo Company.
  • Active ingredients: Cetirizine Hydrochloride and Prednisolone sodium phosphate.
  • Inactive Ingredients: Corn starch, hypromellose, lactose monohydrate, magnesium stearate, polydextrose, polyethylene glycol, povidone, titanium dioxide, triacetin, FD&C Blue No. 1. Note: Inactive ingredients may vary.
  • NDC Code: 45802-0919, 00113-9458.

Available forms of 4H2 pill

  • 4H2 Capsules and Tablets
  • 4H2 Chewable Tablets
  • 4H2 Orally Disintegrating Tablets
  • 4H2 oral syrup


How does the 4H2 pill work?

The active ingredients of 4H2 that constitute its action are Prednisolone sodium phosphate and Cetirizine Hydrochloride.

Cetirizine and Prednisolone sodium phosphate, the active ingredients in the 4H2 pill, are both non-sedating antihistamines that act by inhibiting histamine (H-1) receptors.

Histamine is a chemical that causes many of the signs and symptoms associated with allergic responses, such as nasal swelling, sneezing, and itchy eyes. 


How should you use 4H2 pills?

To get the most out of the 4H2 pill, you gotta know how to use it. The recommended maximum adult dosage for 4H2 Pill is one tablet daily. 

Before taking this drug, read all of the instructions on the product box if you are using it to self-treat. Consult your pharmacist if you have any queries.

Take this medicine as suggested by your doctor, generally once daily.

If you're taking chewable pills, chew each one well before swallowing. Allow the fast dissolving tablet to dissolve on the tongue before swallowing it, with or without water.

If you are taking this medicine in liquid form, carefully measure the dosage using a proper measuring device/spoon. If you use a regular spoon, you may not obtain the exact dosage.

This medication may be used with or without meals. Take the capsules with a glass of water.

The dose is determined by your age, medical condition, and treatment response. Do not raise your dosage or use this drug more often than prescribed.

Inform your doctor if your allergy symptoms do not improve after 3 days of therapy, or if your hives linger longer than 6 weeks.

If your health worsens or you suspect you have a major medical issue (such as a severe allergic reaction/anaphylaxis), get medical attention immediately.

Dosing instructions for the 4H2 pill

  1. Adult Dosage for Allergic Rhinitis
  • 5 to 10 mg taken orally once a day.
  • Maximum daily dosage: 10 mg.

2. Adult Dosage for Urticaria

  • 5 to 10 mg taken once a day orally.
  • Maximum daily dosage: 10 mg.

3. Pediatric Dosage for Allergic Rhinitis

From six months until two years:

  • Initial dosage: 2.5 mg taken orally once a day.
  • Maintenance dosage: 2.5 mg taken orally once or twice daily.
  • Maximum daily dosage: 5 mg.

2 to 5 years old:

  • Initial dosage: 2.5 mg taken orally once a day.
  • Maintenance dosage: 2.5 mg taken orally twice a day or 5mg taken orally once daily.
  • Maximum daily dose: 5 mg.

6 years and older: 

  • 5 to 10 mg taken orally once a day.
  • Maximum daily dose: 10 mg.

4. Pediatric Dosage for Urticaria 

From six months until two years:

  • Initial dosage: 2.5 mg orally once a day
  • Maintenance dose: 2.5 mg orally once or twice a day.
  • Maximum daily dose: 5 mg.

2 to 5 years old:

  • Initial dosage: 2.5 mg taken orally once a day.
  • Maintenance dosage: 2.5 mg orally twice a day or 5 mg orally once daily.
  • Maximum daily dose: 5 mg.

6 years and older:

  • 5 to 10 mg taken orally once a day. 
  • Maximum daily dose: 10 mg

These dosages are also used to treat the following;

  • Relief of symptoms associated with allergen-induced perennial allergic rhinitis (e.g., sneeze, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tears) in patients 2 years and older.
  • Treatment of patients 6 months and older with simple cutaneous symptoms of chronic idiopathic urticaria.

According to some specialists, patients over the age of 65 should begin with 5 mg orally once daily.

What if I miss a dose of the 4H2 pill?

Nothing much will happen. Just that if you have missed significant doses of the drug, it will not be effective or potent enough to treat you for the ailment you took it for.

Do the following if you have miss dosed;

  • If you forget to take one or more doses: take your next dose at the usual time and in the average amount. Do not take anymore than your doctor prescribed.
  • If you miss one dose, skip it and continue with your normal schedule.
  • Do not increase the dosage, to catch up with the missed doses.
  • You should consult your doctor on what to do if you don’t know what to do.

What if I overdose on the 4H2 pill?

According to a study, taking an overdose of tablet 4H2 pill has no advantage.

Call 911 or the healthcare provider in your area if someone has overdosed and is experiencing significant symptoms like passing out or difficulty breathing.

Otherwise, contact a poison control center immediately. Residents in the United States may contact their local poison control center at 1-800-222-1222.

Residents of Canada may contact a provincial poison control center. Overdose symptoms may include extreme sleepiness. Before sleepiness, children may experience mental/mood disturbances (such as restlessness or irritability).


What are the benefits or uses of the 4H2 pill?

4H2 pill is a very powerful and strong drug used to treat allergy symptoms associated with Asthma, Rhinitis, and Urticaria. This includes symptoms like:

  • A runny nose
  • Teary eyes
  • Sneezing
  • Skin itching
  • Hives

Cetirizine and Prednisolone sodium phosphate, the active or main ingredients of the 4H2 pill, are antihistamines that are used to treat allergy symptoms such as those mentioned above.

They work by inhibiting the production of a natural chemical (histamine) by your body during an allergic response.


Are there any side effects of the 4H2 pill?

Like all medicines, 4H2 10 mg Tablets can cause side effects, although not everybody gets them. The following side effects have been reported in post-marketing experience:

  1. Gastrointestinal disorders
  • Common: dry mouth, nausea (feeling sick), diarrhea, vomiting, abdominal pain.
  • Rare: Severe abdominal pain and dyspepsia.
  • Incidence not known: Tongue disorder, constipation, flatulence, increased salivation, aggravated tooth caries, eructation, gastritis, hemorrhoids, melena, rectal hemorrhage, stomatitis/ulcerative stomatitis, tongue discoloration/edema, enlarged abdomen.

2. Blood and lymphatic disorders

  • very rare: thrombocytopenia (low levels of blood platelets).
  • Incidence not known: Lymphadenopathy.
  • Postmarketing surveillance (PMS): Thrombocytopenia, hemolytic anemia.

3. Hypersensitivity

  • Incidence not known: Allergic reactions/delayed allergic reactions.
  • PMS: Hypersensitivity, anaphylactic shock.

4. Musculoskeletal disorders

  • Very rare: Myelitis.
  • Incidence not known: Back pain, myalgia, arthralgia, bone disorder/fracture, leg cramps, arthritis, arthrosis, muscle weakness.

5. Cardiac disorders

  • Rare: Tachycardia (heart beating fast).
  • Incidence not known: Flushing, palpitations, tachycardia, edema/general edema, chest pain, cardiac failure, hypertension, hot flashes, peripheral edema, pallor.
  • PMS: Severe hypotension.

6. Eye disorders

  • Uncommon: Accommodation disorder (lack of the ability of the eye to focus), oculogyration (movement of eyes in an uncontrolled circular manner), and blurred vision.
  • Incidence not known: Eye abnormality, periorbital edema, abnormal vision, eye pain, conjunctivitis, ptosis, visual field defects, blindness, glaucoma, ocular hemorrhage, xerophthalmia, periorbital edema/eye swelling.
  • PMS: Accommodation disorder/loss of accommodation, blurred vision, oculogyration, orofacial dyskinesia

7. General disorders and administration site conditions

  • Rare: asthenia (feeling of weakness), malaise (feeling of being generally unwell), edema (swelling).

8. Immune system disorders

  • Rare: allergic reactions, some severe.

 9. Hepatobiliary disorders

  • Rare: liver function abnormal
  • Incidence not known: Reversible transaminase elevations
  • PMS: Abnormal hepatic function (increased transaminases, alkaline phosphatase, GGT, bilirubin), cholestasis, hepatitis.

10. Psychiatric disorders

  • Common: Somnolence (sleepiness) 
  • Rare: Aggression, depression, agitation, tics (sudden abnormal repetitive muscle movement), confusion, insomnia (difficulty in sleeping), hallucination.
  • Incidence not known: Nervousness, impaired concentration, confusion, decreased libido, abnormal thinking, anxiety, depersonalization, emotional lability, euphoria, paronychia, sleep disorder
  • PMS: Agitation, aggression/aggressive reaction, depression, hallucination, tic, suicidal ideation/suicide

11. Renal and urinary disorders

  • Rare: Abnormal elimination of urine.
  • Incidence not known: Polyuria, urinary retention, urinary tract infection, dysmenorrhea, hematuria, micturition frequency, urinary incontinence, female breast pain, intermenstrual bleeding, leukorrhea, menorrhagia, vaginitis, and Cystitis.
  • PMS: Dysuria, enuresis, and glomerulonephritis.

12. Skin and subcutaneous tissue disorders

  • Rare: Pruritus (itching), rash rare: urticaria (swelling, redness, and itchiness of the skin), edema (swelling), fixed drug eruption.
  • Incidence not known: Pruritus/intense itching, increased sweating, acne, alopecia, bullous eruption, dermatitis, dry skin, eczema, erythematous rash, furunculosis, hyperkeratosis, hypertrichosis, maculopapular rash, photosensitivity/photosensitivity toxic reaction, purpura, seborrhea, skin disorder/nodule
  • PMS: Rash, urticaria, angioneurotic edema, fixed drug eruption, acute generalized exanthematous pustulosis.

13. Respiratory system disorders

  • Common: Pharyngitis (sore throat), rhinitis (swelling and irritation inside the nose), coughing, epistaxis.
  • Incidence not known: Dyspnea, respiratory disorder, bronchospasm, upper respiratory tract infection, dysphonia, bronchitis, hyperventilation, increased sputum, pneumonia, sinusitis, nasal polyp.

14. Nervous system disorders

  • Common: Headache and Dizziness.
  • Rare: Paraesthesia (abnormal feelings of the skin), dysgeusia (altered taste), tremor, syncope (fainting), movement disorders, and convulsions.
  • Incidence not known: Loss of memory, memory impairment, Altered sense of taste, paresthesia, hypertonia, tremor, abnormal coordination/incoordination, ataxia, hyperesthesia, hyperkinesia, hypoesthesia, migraine, paralysis, twitching, parosmia, taste loss/perversion.
  • PMS: Convulsions, dysgeusia, dyskinesia, dystonia, syncope, amnesia, vertigo, memory impairment.

15. Metabolic disorders

  • Incidence not known: Increased appetite, anorexia, increased weight, dehydration, diabetes mellitus.

Other side effects

  • Common: Fatigue
  • Incidence not known: Earache, tinnitus, fever, pain, rigor, thirst, deafness, ototoxicity, accidental injury, face edema, leg edema, malaise
  • PMS: Asthenia, stillbirth

Drowsiness, weariness, and dry mouth are all possible side effects. Stomach discomfort is also possible, particularly in youngsters. Inform your doctor or pharmacist right once if any of these symptoms persist or worsen. Consult your doctor right away if you have any of the following negative effects;

  • A relaxed and calm feeling
  • Acid or sour stomach
  • Belching
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • Change or loss of taste
  • Feeling hot
  • Headache
  • Heartburn
  • Increased sweating
  • Indigestion
  • Stomach discomfort, upset, or pain
  • Incidence not known: Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

If your doctor has recommended this medicine, keep in mind that your doctor has determined that the benefit to you outweighs the risk of side effects.

Many people who use this drug have no serious side effects. Inform your doctor immediately away if you have any major side effects, such as problems urinating or weakness.

It is uncommon for this medicine to cause a severe allergic response.

However, get medical attention immediately if you detect any of the following signs of a severe allergic reaction: rash, itching/swelling (particularly of the face/tongue/throat), extreme dizziness, and difficulty breathing.

Contact your doctor or pharmacist if you experience any additional side effects not mentioned above.

In the United States, contact your doctor for medical advice concerning side effects. You may report adverse effects to the FDA by calling 1-800-FDA-1088 or visiting

In Canada, contact your doctor if you are experiencing adverse symptoms. You may contact Health Canada at 1-866-234-2345 to report adverse effects.

In your area, you can call your healthcare provider for help.

Negative impacts of taking the medicine commonly occur when you take this medicine without a proper prescription or misuse it.


Precautions for using 4H2 pills

4H2 should not be taken;

  • If you have severe kidney disease (renal failure with a creatinine clearance of less than 10 ml/min).
  • If you are known to be allergic (hypersensitive) to the active components in 4H2 (Cetirizine and Prednisolone sodium phosphate) or any of the pills' other constituents.
  • If you have a history of hydroxyzine hypersensitivity (closely related to active substances of other medicines).
  • If you have a known allergy (hypersensitivity) to medications in the piperazine family, such as buclizine, cyclizine, meclizine, or levocetirizine.
  • If you have a sugar allergy unless your doctor instructs you otherwise (this medicine contains lactose).

Other things to note;

  • Tell your doctor or pharmacist if you are allergic to cetirizine, hydroxyzine, or levocetirizine, or if you have any additional allergies. Inactive chemicals in this product may cause allergic reactions or other complications. For further information, see your pharmacist.
  • Tell your doctor or pharmacist about your medical history, particularly if you have problems urinating (such as from an enlarged prostate), renal disease, or liver illness before taking this medicine.
  • If you are using this drug to treat hives, notify your doctor immediately away if you have any of the following symptoms, which might indicate a more severe condition: hives that are an odd hue, hives that seem bruised, or blistered, and hives that do not itch.
  • This medication may cause drowsiness. You may get drowsier if you consume alcohol or marijuana (cannabis). 
  • Do not drive, operate equipment, or do anything else that requires attentiveness until you are sure you can do it safely. Consume non-alcoholic drinks. If you use marijuana, see your doctor (cannabis).
  • Sugar may be present in liquid goods. If you have diabetes, proceed with caution. Inquire with your doctor or pharmacist about the safe use of this product.
  • Inform your doctor or dentist about all of the products you consume before undergoing surgery (including prescription drugs, nonprescription drugs, and herbal products).

Breastfeeding and pregnancy

This drug should be taken only when necessary during pregnancy. Consult your doctor about the dangers and advantages.

This medicine is excreted in breast milk. Before breastfeeding, consult your doctor.

Before taking any medication, consult your doctor. People especially, pregnant women, should avoid using 4H2 pills without a prescription.

Accidental drug usage by a pregnant woman should have no negative consequences on the fetus. Nonetheless, the medication should no longer be administered.

4H2 should not be used during breastfeeding since 4H2 goes into breast milk.

Driving and operating machinery

There is no indication of reduced attention, alertness, or driving skills after taking 4H2 at the indicated dosage, according to clinical investigations.

If you plan to drive, operate equipment, or conduct other duties that need your entire attention, do not exceed the suggested dose and constantly monitor your reaction to the medicine.

If you are a sensitive patient, the concurrent use of alcohol or other nerve depressive medications may impair your attention and capacity to respond.

Skin allergy test

If you are having an allergy skin test, you should stop taking 4H2 pills three days before the test.


Are there any drug interactions of 4H2?

Drug interactions might alter the way your prescriptions operate or put you at risk for dangerous side effects. This guide may not include every conceivable medication interaction.

Maintain a list of all the items you take (including prescription and nonprescription medicines, as well as herbal supplements) and discuss it with your doctor and pharmacist.

Do not start, stop, or modify the dose of any medications without first consulting your doctor.

Tell your doctor or pharmacist if you are taking any other drowsy medications, such as opioid pain relievers (codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (alprazolam, lorazepam, zolpidem), muscle relaxants (carisoprodol, cyclobenzaprine), or other antihistamines (such as chlorpheniramine, diphenhydramine).

Check the labels of all your medications (such as allergy or cough-and-cold remedies) since they may include drowsy chemicals. Inquire with your pharmacist about how to use such products properly.

Use with caution if combined with other antihistamines applied to the skin (such as diphenhydramine cream, ointment, or spray), since higher adverse effects may develop.

Cetirizine is chemically related to hydroxyzine and levocetirizine. Do not take these drugs if you are taking 4H2.

Most frequent interactions

249 medications may interact with 4H2, but I will not drop all 249 here. I will only give info on the frequent interactions known.

Not all 249 interactions are serious or even common, and some do not even exist anymore because medicine is evolving every day, and getting better, to avoid any unneeded interactions between drugs to get better and more efficient when you take your medications.

So I am only gonna give you the interactions worth mentioning. But if you still wanna view all 249 interactions, you can do that via this link: 249 drug interactions of 4H2.

Moderate and minor medicine interactions with 4H2

  • Benadryl (diphenhydramine)
  • Cymbalta (duloxetine)
  • Lyrica (pregabalin)

Major and serious medicine interactions with 4H2

  • Aspir 81 (aspirin)
  • Aspirin Low Strength (aspirin)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • Miralax (polyethylene glycol 3350)
  • Nexium (esomeprazole)
  • ProAir HFA (albuterol)
  • Singulair (montelukast)
  • Symbicort (budesonide / formoterol)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Ventolin HFA (albuterol)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)

Disease Interactions of 4H2

There are 2 disease interactions with 4H2, though both are moderate.

The first one is acute alcohol intoxication: When using 4H2 or other antihistamines, you should avoid drinking alcohol. Drowsiness caused by 4H2 may be exacerbated by the use of alcohol, sedatives, and tranquilizers.

The second one is Renal Dysfunction: 4H2 is mostly removed through the kidney, although it is also partially metabolized in the liver.

Patients with renal and/or hepatic dysfunction may be more susceptible to 4H2 side effects owing to poor medication clearance.

In patients 6 years of age and older with diminished renal function and/or impaired hepatic function, the manufacturer suggests a starting dose of 5 mg once a day.

Because of the difficulties in consistently giving doses lower than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this group, 4H2 should ideally not be used in children less than 6 years of age with renal and/or hepatic impairment.

Taking 4H2 Pills with alcohol and food

Food has no discernible effect on 4H2 absorption. Furthermore, no significant interactions between alcohol (at a blood level of 0.5 per mille (g/l), equivalent to one glass of wine) and 4H2 at the prescribed levels have been detected. 

However, like with other antihistamines, it is advised to avoid alcohol intake while taking this medication, since alcohol may exacerbate the nervous system's adverse effects of 4H2, such as dizziness, sleepiness, and difficulties focusing. 

Some persons may also develop cognitive and judgment impairment. While using 4H2, you should avoid or restrict your alcohol consumption. 

Use 4H2 only as directed, and avoid tasks that need mental alertness, such as driving or operating dangerous equipment, until you know how the medicine affects you. 

If you have any questions or concerns, see your doctor or pharmacist.


Is 4H2 safe for me?

Yeah, it is. I have already given you the idea and content you need to know on when you have to take and not take 4H2 in the precautions section of this article. 

4H2 is only safe if you use it as prescribed. If you observe any side effects while taking this medication as instructed, then these side effects are minimal and common and will pass away with time as the drug loses its potency.

Although the long-term use of 4H2 is not recommended. If you take 4H2 over an extended period, it is unlikely to cause side effects.

However, it is better to just take 4H2 for as long as necessary. If you take it consistently over a long length of time, there is a very tiny probability of withdrawal symptoms like severe itching if you abruptly discontinue therapy.

To be on the safe side, always consult your doctor before taking certain medications like this 4H2, because there might be certain conditions you are in like pregnancy, breastfeeding, young age, and old age that taking medications like 4H2 will be harmful to you.

So always see your doctor first, because he/she will know if the benefits of the medication you are taking outweigh the side effects, or if it is safe for you.


Is 4H2 a Controlled Drug?

No, under the Prohibited Substances Act, 4H2tablet is not a controlled drug (CSA). 

However, some public health professionals are advocating for the prescription to be classed as a prohibited substance because of the drug's haphazard usage, which is creating a public health issue. 

Illicit drug addicts snort 4H2Pill to acquire a high, a technique fraught with many health risks.


Is 4H2 available in a generic version?

Yeah, it is. Its generic version is available in the following brands;

  • Zyrtec (Cetirizine)
  • Aller-Tec
  • Children's Zyrtec
  • All Day Allergy.


What other alternative medications can you use in place of 4H2?

Alternatives to 4H2 include;

  • Chlorpheniramine
  • Dexchlorpheniramine
  • Hydroxyzine
  • Claritin (loratadine)


What is the cost of the 4H2 pill?

The cost for 4H2 medicine ranges from $0.04 to $500 depending on the form of the medication you buy and the pharmacy you visit.

Prices are for cash-paying customers only and are not valid with insurance plans.

This 4H2 price guide below is based on using the discount card which is accepted at most U.S. pharmacies.

Check the 4H2 Oral Syrup price via this link: 1mg/ml 4H2 oral syrup.

Check the 4H2 Oral Tablet price via this link: 5 mg 4H2 oral tablet and 10 mg 4H2 oral tablet.

Check the Chewable Oral tablet price via this link: 5 mg 4H2 chewable oral tablet and 10 mg 4H2 oral tablet.

Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee. Printable Discount Card: The free Discount Card works like a coupon and can save you up to 80% or more of the cost of prescription medicines, over-the-counter drugs, and pet prescriptions.

Please note: This is a drug discount program, not an insurance plan. Valid at all major chains including Walgreens, CVS Pharmacy, Target, Walmart Pharmacy, Duane Reade, and 65,000 pharmacies nationwide.

4H2 Coupons and Rebates

4H2 offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples.

Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.

There are currently no Manufacturer Promotions that we know about for this drug.

Patient Assistance Programs for 4H2

Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low-income or uninsured and under-insured people who meet specific guidelines.

Eligibility requirements vary for each program. There are currently no Patient Assistance Programs that we know about for this drug.


Where can I buy 4H2?

It can be bought at your local pharmacy, hospitals, and online drug stores like,, and


How do you store 4H2?

Oral solution: Protect against the light.

Oral liquid gel tablets: Keep away from dampness, light, and temperatures exceeding 40 degrees Celsius.

Store away from light and moisture at room temperature. Keep out of the bathroom. This medication's storage requirements may change depending on the brand. 

Check the product label or contact your pharmacist for information on how to keep your brand. Keep all drugs out of the reach of children and dogs.

Unless otherwise directed, do not flush drugs or pour them down the drain. When this product has expired or is no longer required, properly dispose of it. 

Consult your pharmacist or a garbage disposal firm in your area.


The takeaway on the 4H2 pill by Healthsoothe

4H2 works by inhibiting the production of a natural chemical (histamine) by your body during an allergic response, which is hazardous when stored in the body.

4H2 should not be used to treat severe allergic reactions (such as anaphylaxis). If your doctor has ordered epinephrine to treat allergic reactions, keep your epinephrine injector with you at all times.

4H2 should not be used in place of epinephrine. Take extra precautions while using 4H2 Pills.

4H2 tablets contain lactose; if your doctor has warned you that you are lactose intolerant, please consult with your doctor before taking this medication.

If you have renal difficulties, please see your doctor; you may need to take a lesser amount. Your doctor will decide on the new dosage.

If you have epilepsy or are in danger of having convulsions, you should see your doctor.

Although there is no documented danger in people during pregnancy, it is always advisable to take this medication after consulting with your doctor.

If you are a doctor who is administering this medication to a patient, be sure to do the following: 

  • Inform patients that this medication may induce drowsiness and that they should avoid driving or operating equipment until the full effects of the medication are observed.
  • Allergic responses should be reported promptly by patients.
  • Make sure they understand all they need to know about the medicine.

4H2 is an antihistamine that efficiently cures allergic responses such as hay fever and insect bite skin reactions.

Although sleepiness caused by 4H2 is infrequent, it is more likely to produce drowsiness than loratadine.

This medicine may cause erroneous test findings in some laboratory tests (including allergy skin testing).

Make certain that laboratory workers and all of your physicians are aware that you are taking this medication.

Please notify your doctor or pharmacist if you are currently taking or have recently taken any additional medications, including over-the-counter medications.

4H2's profile suggests that no interactions with other medicines are likely if the medication is taken as instructed.

You can always check our FAQs section below to know more about 4H2.


Frequently Asked Questions about 4H2

Can 4H2 Get You High?

Yes, you can get pseudo-high on 4H2 because of the side effects of overdosing on 4H2, but if you take 4H2 as prescribed by your doctor, there is no way you can get high on it.

Illicit drug addicts snort the 4H2 Pill to acquire a high, a technique fraught with many health risks.

How many 4H2 pills can you take in a day?

The recommended maximum adult dosage for 4H2 Pill is one tablet daily. Taking an overdose of 4H2 provides no benefit, according to research.

Are cetirizine and prednisolone the same?

No, they ain’t. They are different substances, but the only thing similar between them is that they are both used to treat the same thing, and they are also the main ingredients of 4H2 pill.

Prednisolone is an effective treatment for eye redness and swelling that does not expose the rest of your body to steroid medication.

It is also used to relieve allergy problems. Cetirizine also assists with allergy symptoms without making you tired. It also helps to reduce edema and redness in the eyes.

Is 4H2 the same as Cetirizine Hydrochloride?

Yeah, the 4H2 pill has been identified as Cetirizine Hydrochloride, because it’s one of its main active ingredients.

Should the 4H2 pill be taken at bedtime or upon awakening? And before or after any particular meal?

4H2 can be taken at any time of the day. In most people it is non-sedating, so they take it in the morning. However, a percentage of people do find it to be sedating so if it does make you drowsy it is best to take it in the evening.

4H2 can be taken with or without food.

Can you take Benadryl and 4H2 together?

Benadryl should not be taken at the same time as 4H2 because it can increase side effects such as dizziness, drowsiness, and difficulty concentrating.

Some people, especially the elderly or children, may also find their thinking, judgment, and coordination impaired.

You should also not drink alcohol while taking either of these medications because it can make these side effects worse.

How long after taking 4H2 can I drink alcohol?

It is best to wait until 4H2 completely leaves your body before you drink alcohol, which may take up to 40 hours (almost 2 days).

This is because alcohol can increase the nervous system side effects of 4H2 such as dizziness, drowsiness, and difficulty concentrating.

Some people may also find it difficult to think or make good judgments.

This calculation is based on the half-life of 4H2, which is 8.3 hours, and experts say it takes 4 to 5 half-lives for a drug to fully leave your body which works out to 33 to 40 hours.

Can 4H2 raise blood pressure?

4H2 does not increase blood pressure and blood pressure is not listed as a side effect in the product information.

But 4H2 can be found in combination with other medications, such as pseudoephedrine in products such as Zyrtec-D, and pseudoephedrine does increase blood pressure.

Can 4H2 be taken by kids?

Children aged 2 and over can take 4H2 syrup bought from pharmacies or prescribed by their doctor. Children aged 6 and over can take 4H2 tablets and syrup that you buy from pharmacies and supermarkets.

Is it OK to take 4H2 every day?

Is 4H2 safe to take every day? It is safe to take every day if you have allergy symptoms daily. If you don't have allergy symptoms every day, you can take it as needed on days when these symptoms bother you.

Can you have withdrawals from 4H2?

For example, some people experience symptoms with 4H2 if they take it for a while and then stop suddenly.

The main withdrawal symptom is called pruritus— itching and burning sensations of the skin ranging from moderate to severe.

Can you take 4H2 long-term? 

If you take 4H2 over an extended period, it is unlikely to damage you. However, it is better to just take 4H2 for as long as necessary.

If you take it consistently over a long length of time, there is a very tiny probability of severe itching if you abruptly discontinue therapy.

Can you get addicted to 4H2?

Yeah, you can be addicted to 4H2 if you are prone to drug addictions, are already a drug addict, or like taking hard drugs that get you pseudo-high like cocaine and marijuana.

Illicit drug addicts snort 4H2Pill to acquire a high, a technique fraught with many health risks.

Editorial Review Ratings
It is available without a prescription in many places, making it convenient for individuals to purchase and use for the relief of allergy symptoms without needing to visit a healthcare provider
It provides all-day allergy relief with just a single daily dose, making it easy to use
Most people can take 4H2 pill without experiencing severe side effects
When taken as directed, the 4H2 pill can provide relatively quick relief from allergy symptoms, allowing individuals to resume their daily activities with greater comfort
It is widely available in pharmacies, grocery stores, and online, making it easily accessible for those in need of relief from allergy symptoms
Despite being less sedating, some people may still experience drowsiness or fatigue
Another common side effect is dry mouth, which can be bothersome and uncomfortable for some individuals, leading to increased thirst and difficulty swallowing
It may interact with other medications, especially those that have sedative effects, potentially increasing the risk of drowsiness or other adverse effects.
People with severe kidney disease or those who are allergic to its components can not take cetirizine, thereby limiting its use in certain population
Some individuals might experience gastrointestinal discomfort or pain

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