Post-SSRI sexual dysfunction, abbreviated as PSSD, manifests in individuals after discontinuing antidepressants. The exact prevalence remains unknown due to limited research, partly attributed to inconsistencies in medical community perspectives on diagnosis. Despite this, existing research suggests its widespread occurrence.

While some encounter sexual side effects while on SSRIs, PSSD refers to a prolonged condition affecting those who have ceased medication. Professor David Healy from Bangor University, an expert in psychology, highlights the condition's prevalence.

He notes that about 10 percent of sexually active individuals in developed countries chronically use antidepressants, potentially leaving nearly 20 percent of the population unable to engage in satisfying intimacy. He emphasizes that this figure may be higher in certain disadvantaged areas.

He also warns against the misconception of returning to normalcy post-treatment, suggesting that individuals prescribed SSRIs may experience even greater difficulties functioning.

Healy's research outlines core PSSD features such as genital numbing, diminished or muted orgasms, and loss of libido. Additional concerns include emotional numbing and derealization. Despite people reporting symptoms to regulators since 1999, PSSD was officially documented in medical literature in 2006.

In nearly all cases, individuals with PSSD experienced some form of sexual dysfunction while taking antidepressants and continue to do so after discontinuation.

Certified psychotherapist Alessio Rizzo emphasizes the importance of recognizing PSSD early, understanding its complexity, and acknowledging it as a significant factor in individuals ceasing antidepressant medication, potentially exacerbating symptoms alongside withdrawal.

Who is most affected by PSSD?

PSSD can impact anyone, as sexual dysfunction itself can affect individuals across all genders, ages, and ethnicities, without clear correlations to conventional parameters. Alessio Rizzo notes that the condition does not seem to be associated with specific demographic factors, emphasizing its broad-reaching nature.

Rizzo further explains that individuals more susceptible to depression and anxiety, such as those in the LGBTQ community, are not predetermined to experience mental health issues. However, they may face a higher likelihood of developing conditions like depression and anxiety.

He cautions against pathologizing dysfunction exclusively as a concern for the LGBTQ community and sexual abuse survivors, as this could deter individuals who don't identify with these experiences from seeking help.

Prior to taking antidepressants, approximately 30-50 percent of people experience mild forms of sexual dysfunction. This implies that pre-existing symptoms could be intensified by medication.

Additionally, it raises the possibility that factors beyond antidepressants, such as pain, sensitivity, and past trauma, may contribute to the dysregulation of the sexual response cycle. These factors collectively are referred to as predispositions.

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Pros and Cons of Post-SSRI Sexual Dysfunction

Pros of Post-SSRI Sexual Dysfunction (PSSD)

  • Increased Awareness
  • Research Opportunities
  • Holistic Approach

Cons of Post-SSRI Sexual Dysfunction (PSSD)

  • Negative Impact on Quality of Life
  • Limited Treatment Options
  • Stigmatization of Antidepressants
  • Underreported and Understudied

Differences Between Post-SSRI Sexual Dysfunction and focalin


SSRIs are prescribed to alleviate symptoms of mood disorders by increasing serotonin levels in the brain.


Focalin is prescribed to manage symptoms of ADHD by increasing the levels of dopamine and norepinephrine in the brain.

Alternative to Post-SSRI Sexual Dysfunction

Switching Antidepressants

In some cases, a healthcare provider may consider switching to a different class of antidepressant that is less likely to cause sexual side effects. Bupropion is an example of an antidepressant that may have a lower risk of sexual dysfunction.

Sexual dysfunction of any kind can be a tremendously isolating experience.

Taking a holistic approach to the healing process is crucial, recognizing that while medications contribute to mood stabilization, talk therapies like Cognitive Behavioral Therapy (CBT) play a pivotal role in supporting healing. CBT helps modify thought pathways through neuroplasticity, enabling individuals with pre-existing symptoms or predispositions to sexual dysfunction to identify and address disruptions in their pleasure response cycle in a safe environment.

Discussing sexual issues often invokes feelings of shame, compounded by cultural stigmas surrounding mental health and sexuality. A study by the National Library of Medicine reveals that young people, in particular, may experience shame when discussing sexual experiences, especially if problems are involved. Consequently, any form of sexual dysfunction becomes an isolating experience, intensifying internal turmoil, exacerbated by the corrosive effects of depression and anxiety on self-esteem.

SSRIs, by increasing serotonin levels in the brain, impact the anatomical structures of the reproductive system. This can lead to difficulties such as the inability to maintain or achieve an erection, vaginal dryness, ejaculation issues, and anorgasmia. The inhibition of nitric oxide production by SSRIs significantly affects the body's ability to relax, hindering blood flow to the genitals.

PSSD is a distressing condition without a currently established treatment. The syndrome lacks widespread understanding among researchers, with no consensus on its origins. The hope lies in future research, exploring potential answers in individuals who do not develop PSSD. Only time will reveal if such insights emerge from ongoing investigations.

Sexual Dysfunction Symptoms may include:

  • Diminished genital sensation, often referred to as genital anesthesia
  • Erectile dysfunction in males or decreased vaginal lubrication in females
  • Delayed or inability to achieve orgasm, known as anorgasmia
  • Experiencing pleasureless, weak, or "muted" orgasms
  • Reduced libido or sexual desire
  • Attenuated response to sexual stimuli
  • Decreased or absence of nocturnal erections
  • Premature ejaculation, a condition where climax occurs too quickly
  • Reduced sensitivity in nipple areas
  • Softening of the glans (head of the penis) or loss of penile/clitoral size

Cognitive/other symptoms may include

  • Diminished intensity of emotions, especially in the context of romantic love
  • Anhedonia, characterized by an inability to experience pleasure in various aspects of life
  • Memory loss or difficulties with recall
  • Sleep-related problems or disturbances
  • Depersonalization, a sense of detachment from oneself
  • Reduced drive or motivation to engage in activities
  • Loss of creativity, marked by a decline in imaginative and inventive thinking
  • Difficulty maintaining focus or concentration


The impact of Post-SSRI Sexual Dysfunction (PSSD) extends beyond the physical realm, affecting various aspects of an individual's emotional and psychological well-being. The wide array of symptoms, ranging from reduced genital sensation to diminished intensity of emotions, highlights the complexity of this condition. Taking a holistic approach to healing becomes imperative, incorporating not only medical interventions but also therapeutic strategies such as Cognitive Behavioral Therapy (CBT) to address the intricate interplay between mood, cognition, and sexual function.

Moreover, the stigma surrounding sexual health and mental well-being, coupled with the isolating nature of sexual dysfunction, underscores the importance of fostering open conversations and reducing societal taboos. It is crucial to recognize that PSSD can impact individuals across diverse demographics, emphasizing the need for inclusive and empathetic healthcare practices.

As research continues to delve into the understanding and treatment of PSSD, the journey toward effective solutions remains ongoing. The hope lies in future investigations that may shed light on the mechanisms behind PSSD, paving the way for targeted therapies and support for those grappling with this distressing condition. Until then, raising awareness, promoting dialogue, and offering comprehensive care are essential steps in alleviating the challenges faced by individuals affected by PSSD.

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