Cimetidine is a pharmaceutical that decreases stomach acid levels, effectively addressing issues like heartburn, stomach ulcers, and reflux disease. It is available in tablet form, intended for oral consumption with water according to the prescribed guidelines. Adhere to the instructions provided on the label, and it is recommended to take this medication before bedtime.

What is this medication?

Cimetidine (pronounced sye MET i deen) is utilized to address heartburn, stomach ulcers, reflux disease, and various conditions associated with excessive stomach acid. Its mechanism involves the reduction of stomach acid levels.

It's possible that this medication may have other applications; if you have any inquiries, consult your healthcare provider or pharmacist.

This medicine is commonly known by brand names such as Acid Reducer, Major Acid Reducer, Tagamet, and Tagamet HB.

What should I tell my care team before I take this medication?

It is essential to inform your healthcare provider if you have any of the following conditions:

  • Presence of blood in stools (manifested as black or tarry stools) or if there is blood in vomit.
  • Kidney disease.
  • Liver disease.
  • Difficulty or pain while attempting to swallow food.
  • Any unusual or allergic reactions to cimetidine, other medications, foods, dyes, or preservatives.
  • Pregnancy or if you are attempting to become pregnant.
  • Breastfeeding.

How should I use this medication?

Administer this medication orally, adhering to the guidelines on the prescription label. Swallow the tablets with a beverage of water. If you are prescribed to take this medication once daily, do so at bedtime. Maintain a regular schedule for your doses and refrain from exceeding the recommended frequency.

Discuss with your healthcare team about the appropriateness of using this medication in children, as special precautions may be necessary.

In case of an overdose, promptly contact a poison control center or seek emergency medical attention.

Note: This medicine is intended solely for your use. Do not share it with others.

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Pros and Cons of cimetidine

  • Acid Reduction
  • Symptom Relief
  • Ease of Administration


  • Potential Side Effects
  • Interactions
  • Long-Term Use Issues

Differences Between cimetidine and amlodipine


It is primarily used to reduce stomach acid levels and treat conditions such as heartburn, stomach ulcers, and reflux disease.


This medication is a calcium channel blocker used to treat high blood pressure (hypertension) and certain types of chest pain (angina).

Alternative to cimetidine

Ranitidine (Zantac)

Like cimetidine, ranitidine is an H2 blocker used to reduce stomach acid and treat conditions such as heartburn and ulcers. However, it's essential to be aware that ranitidine has been associated with safety concerns, and its availability may be restricted in some regions due to concerns about impurities. Always consult with your healthcare provider for the latest information.

What if I miss a dose?

If you happen to miss a dose, take it as soon as possible. However, if your next scheduled dose is approaching, only take the upcoming dose and avoid taking double or extra doses to compensate for the missed one.

What may interact with this medication?

Avoid taking this medication if you are using any of the following:

  1. Cisapride
  2. Dofetilide
  3. Pimozide

Additionally, be aware of potential interactions with the following substances:

  • Caffeine
  • Carbamazepine
  • Carmustine
  • Delavirdine
  • Female hormones, including contraceptive or birth control pills
  • Itraconazole
  • Ketoconazole
  • Medications for heart rhythm problems
  • Phenytoin
  • Theophylline
  • Warfarin

This list may not cover all possible interactions. Provide your healthcare provider with a comprehensive list of all medicines, herbs, non-prescription drugs, or dietary supplements you use. Inform them about your smoking, alcohol consumption, or use of illegal drugs, as these factors may also affect interactions with your medication.

What should I watch for while using this medication?

Inform your healthcare team if your pain persists or intensifies. It might take several days of taking this medication before you notice an improvement in your symptoms. Complete the entire prescribed course of tablets even if you start feeling better.

Avoid taking aspirin, ibuprofen, or other anti-inflammatory medications unless specifically instructed by your care team, as they may exacerbate your condition.

Refrain from smoking cigarettes or consuming alcohol, as these can aggravate stomach irritation and prolong the healing time for your ulcer.

If you observe black, tarry stools or vomit material resembling coffee grounds, contact your care team immediately, as this could indicate a bleeding ulcer.

Be aware that this medication may lead to a decrease in vitamin B12 levels. Ensure an adequate intake of vitamin B12 while using this medication by discussing your diet and vitamin supplements with your care team.

What side effects may I notice from receiving this medication?

Notify your healthcare team promptly if you experience the following side effects:

  • Allergic reactions, such as skin rash, itching, hives, or swelling of the face, lips, tongue, or throat.
  • Confusion.
  • Hallucinations.

While the following side effects usually do not necessitate immediate medical attention, inform your care team if they persist or become bothersome:

  • Breast swelling or tenderness.
  • Constipation.
  • Diarrhea.
  • Dizziness.
  • Headache.

This list may not encompass all potential side effects. Contact your doctor for medical advice regarding side effects, and report them to the FDA at 1-800-FDA-1088.

Where should I keep my medication?

Take precautions to prevent access by children.

Store the medication at room temperature, maintaining it within the range of 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit). Shield it from light exposure, and ensure the container is tightly closed. Dispose of any unused medication after reaching the expiration date.


It is crucial to follow the prescribed guidelines for taking this medication to effectively address conditions such as heartburn, stomach ulcers, and reflux disease. Communicate promptly with your healthcare team about any adverse reactions or concerns, and adhere to their instructions regarding missed doses. Take note of potential interactions with other medications or substances and maintain open communication about your overall health.

Furthermore, exercise caution in storing the medication, keeping it out of the reach of children, protecting it from light, and ensuring proper closure of the container. Finally, be diligent about discarding any unused medication after its expiration date.

Your well-being is paramount, and by being attentive to these guidelines, you contribute to the effectiveness and safety of your treatment plan. Always consult with your healthcare provider for personalized advice and guidance throughout your course of medication.

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