Sulindac is employed to alleviate arthritis-related pain, swelling, and joint stiffness. Additionally, it is utilized in the treatment of spinal arthritis, gouty arthritis, and shoulder bursitis/tendonitis. As a nonsteroidal anti-inflammatory drug (NSAID), Sulindac operates by inhibiting the body's synthesis of specific natural substances responsible for causing inflammation.

This mechanism contributes to a reduction in swelling, pain, and fever. For individuals managing persistent conditions like arthritis, it is advisable to consult with a healthcare professional regarding non-pharmacological treatments and the potential use of alternative medications for pain management.

How to use Sulindac

Please go through the Medication Guide provided by your pharmacist before initiating sulindac and upon each refill. If you have any inquiries, consult your doctor or pharmacist.

Follow your doctor's instructions and take this medication orally, usually twice a day. Ingest it with a full glass of water (8 ounces/240 milliliters), unless otherwise directed by your doctor. Refrain from lying down for at least 10 minutes after taking the medication. If you experience stomach upset, consume it with food, milk, or an antacid.

The prescribed dosage is contingent on your medical condition and how you respond to the treatment. To minimize the risk of stomach bleeding and other potential side effects, take the medication at the lowest effective dose for the shortest duration possible. Do not escalate your dose or prolong the use beyond the prescribed period. Discuss the associated risks and benefits with your doctor or pharmacist.

For specific conditions, such as arthritis, it may take 1-2 weeks of regular drug intake to experience the full benefits.

If you are using this medication on an "as needed" basis (not on a regular schedule), keep in mind that pain relief is most effective when administered at the onset of pain. Delaying until the pain intensifies may diminish the medication's efficacy.

Inform your doctor if your condition deteriorates.

Side Effects

Possible side effects of sulindac include upset stomach, nausea, vomiting, gas, diarrhea, constipation, dizziness, or headache. If any of these symptoms persist or worsen, promptly inform your doctor or pharmacist.

It's important to bear in mind that your doctor has prescribed this medication because they have assessed that the benefits outweigh the risks of potential side effects. Many individuals using this medication do not experience severe side effects.

Sulindac may elevate your blood pressure. Monitor your blood pressure regularly and notify your doctor if the readings are high.

Contact your doctor immediately if you encounter any serious side effects, including changes in hearing (such as ringing in the ears), alterations in mental/mood, easy bleeding/bruising, difficulty/painful swallowing, or symptoms indicative of heart failure (such as swelling ankles/feet, unusual fatigue, sudden/unexplained weight gain).

Seek immediate medical attention if you observe very serious side effects, such as signs of kidney problems (e.g., changes in urine quantity, pink/bloody urine) or an unexplained stiff neck.

While rare, sulindac may potentially lead to serious (possibly fatal) liver disease. Seek prompt medical assistance if you manifest symptoms of liver damage, including persistent nausea/vomiting, loss of appetite, stomach/abdominal pain, yellowing of the eyes/skin, or dark urine.

Although a severe allergic reaction to this drug is uncommon, seek immediate medical help if you experience symptoms such as fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing.

Note that this compilation of potential side effects is not exhaustive. If you notice any other effects not mentioned here, reach out to your doctor or pharmacist for guidance.

Read Also: How and why to use telemedicine to address mental health crises

Pros and Cons of sulindac

Pros of Sulindac

  • Anti-Inflammatory Properties
  • Management of Various Conditions
  • Pain Relief
  • Reduction of Inflammation

Cons of Sulindac

  • Cardiovascular Risks
  • Gastrointestinal Issues
  • Kidney Problems
  • Dizziness and Drowsiness

Differences Between sulindac and ardosons


Primarily used to reduce pain, swelling, and joint stiffness associated with arthritis. It is also employed in the treatment of spinal arthritis, gouty arthritis, and shoulder bursitis/tendonitis.


Commonly prescribed for conditions involving inflammation, such as rheumatoid arthritis, osteoarthritis, and other musculoskeletal disorders. The combination of active ingredients allows for a broader spectrum of therapeutic effects.

Alternative to sulindac


In some cases, corticosteroids may be used as an alternative for their potent anti-inflammatory effects. However, they are typically reserved for short-term use due to potential side effects.


Nonsteroidal anti-inflammatory drugs (NSAIDs, including sulindac) may infrequently elevate the risk of a heart attack or stroke. This potential effect can occur at any point during the course of using the drug but is more likely with prolonged use. The risk may be heightened in older adults or individuals with pre-existing heart conditions or an increased susceptibility to heart disease (e.g., due to smoking, family history, high blood pressure, or diabetes). It is advisable not to take this medication immediately before or after undergoing heart bypass surgery (CABG).

Additionally, there is a rare but serious risk of significant bleeding from the stomach or intestines associated with this drug. This adverse effect can manifest without warning symptoms at any time during treatment, with older adults potentially facing a higher risk.

If you observe any of these uncommon yet severe side effects, cease taking sulindac and seek immediate medical assistance: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

Discuss the potential benefits and risks of using this medication with your doctor or pharmacist to make informed decisions about your treatment.


Before starting sulindac, inform your doctor or pharmacist about any allergies you may have, including allergies to sulindac, aspirin, or other NSAIDs such as ibuprofen, naproxen, or celecoxib. Discuss any other allergies you may have with your pharmacist as inactive ingredients in the product can cause allergic reactions or other complications.

Share your medical history with your doctor or pharmacist, especially if you have a history of asthma (particularly worsening breathing after taking aspirin or NSAIDs), blood disorders (like anemia or bleeding/clotting problems), nasal polyps, heart disease (including prior heart attacks), high blood pressure, kidney stones, liver disease, stroke, swelling (edema or fluid retention), or stomach/intestinal/esophagus problems (such as bleeding, heartburn, or ulcers).

Kidney problems may arise with the use of NSAID medications, including sulindac. The risk is higher if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you are taking certain medications (refer to the Drug Interactions section). Stay adequately hydrated as directed by your doctor and promptly report any signs of kidney issues, such as pink/bloody urine or unusual changes in urine volume.

This medication may cause dizziness. Avoid activities that require alertness, such as driving or using machinery, until you can do so safely. Limit alcohol consumption, and discuss marijuana (cannabis) use with your doctor.

The potential for stomach bleeding increases with the use of this medicine. Combined use with daily alcohol and tobacco may further elevate the risk of stomach bleeding. Limit alcohol intake and cease smoking.

Be cautious about sun exposure, as this medication may increase sensitivity to sunlight. Limit time spent in the sun, avoid tanning booths and sunlamps, and use sunscreen and protective clothing. Inform your doctor promptly if you experience sunburn or skin blisters/redness.

Before undergoing surgery, inform your doctor or dentist about all the products you are using, including prescription drugs, nonprescription drugs, and herbal products.

Older adults may face a higher risk of stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using this drug.

For women of childbearing age, discuss the benefits and risks of using this medication with your doctor. Inform your doctor if you are pregnant or planning to become pregnant. The use of this medication is not recommended from 20 weeks until delivery. If deemed necessary between 20 and 30 weeks of pregnancy, use the lowest effective dose for the shortest duration. Do not use this medication after 30 weeks of pregnancy.

It is uncertain whether this medication passes into breast milk. Breastfeeding is not recommended while using this medication, so consult your doctor before breastfeeding.


If an individual has overdosed and is experiencing severe symptoms such as loss of consciousness or difficulty breathing, call 911 immediately. Otherwise, contact a poison control center without delay. In the United States, residents can reach their local poison control center at 1-800-222-1222, while Canada residents can call a provincial poison control center. Overdose symptoms may encompass severe stomach pain, slow or shallow breathing, extreme drowsiness, and loss of consciousness.

Important Notes

  • Refrain from sharing this medication with others.
  • Regular medical and laboratory tests, such as complete blood count, liver/kidney function, and blood pressure checks, may be conducted while using this medication. Attend all medical and lab appointments, and consult your doctor for additional details.
  • Lifestyle modifications, including weight loss if necessary and strengthening/conditioning exercises, may enhance flexibility and joint function. Seek specific instructions from your doctor.

Missed Dose

  • If you are on a regular schedule for this drug (not just "as needed") and miss a dose, take it as soon as you remember. If it is close to the time of the next dose, skip the missed one, and resume your regular schedule. Do not double the dose to compensate for a missed one.


  • Store this medication at room temperature, away from light and moisture. Avoid storing it in the bathroom. Keep all medications out of reach of children and pets.
  • Do not dispose of medications by flushing them down the toilet or pouring them into a drain unless instructed to do so. Properly discard the product when it expires or is no longer needed. Consult your pharmacist or local waste disposal company for guidance.


The proper use of sulindac is crucial for maximizing its benefits and minimizing potential risks. It's essential to follow your healthcare provider's instructions meticulously, from understanding the Medication Guide to adhering to prescribed dosages. Be vigilant for any adverse effects, especially serious ones like stomach bleeding or kidney problems. In case of an overdose or severe symptoms, seek immediate medical assistance.

Moreover, communication with your doctor about your medical history, allergies, and existing conditions is vital for personalized and safe treatment. Regular monitoring through medical tests and appointments is recommended to ensure the medication's effectiveness and your overall well-being.

Remember not to share sulindac with others, and be cautious about lifestyle choices that can impact its effects. If you miss a dose, follow the appropriate guidelines and never double up on doses.

Lastly, responsible storage and proper disposal of the medication contribute to a safe and effective treatment process. If you have any concerns or questions about sulindac, always consult your healthcare provider for guidance tailored to your specific needs.


My name is Wisdom Bassey, I'm a blog content writer and graphic designer who provides support and services for brands and different companies. I'm young and versatile, A tech enthusiast. I carry out deep research on every topic I choose to write about. You can reach me through my social media handles, I'm always available and ready to connect.

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