Close Menu
    FacebookX (Twitter)Instagram
    Trending
    • 10 Important Things to Know Before Increasing Your Protein Intake
    • Top 6 Oral Health Resolutions for 2025 – Dentist-Approved Tips
    • The Psychology of Happiness: How Genetics, Environment, and Relationships Shape Well-Being
    • A Guide to Telemedicine Services
    • Benefits of Medical Detox for Alcohol and Drug Rehabilitation - Prevention Is Better Than Cure!!
    • How Diagnostic Tests Empower Personalized Medicine – A Complete Guide
    • Thick White Oblong Pills – Types, Uses, Side Effects, and Safety Guide
    • Standards Growth Calculator: Track Healthy Growth for Men, Women, and Children
    FacebookX (Twitter)Instagram
    HealthsootheHealthsoothe
    • Home
    • Healthy
    • Dental Care
    • Skin Care
    • Discover
      • Women hygiene
      • Tragedy Stories
      • Recipes
    • Health Tools
      • Body Tat Calc
      • CALC Diet Calorie
      • Ideal Body Weight Calc
      • Burned Calories Calc
      • View All
    • Connect
      • About us: What You Should Know About Healthsoothe Company
      • Privacy Policy & Affiliate Disclosure
      • Contact us
    HealthsootheHealthsoothe
    WELLNESS HEALTH - Dorixina Relax: Uses, Dosage, Side Effects, and Precautions

    Dorixina Relax: Uses, Dosage, Side Effects, and Precautions

    By Wisdom BasseyUpdated:July 26, 2025
    dorixina relax in english
    Share this post
    FacebookXRedditPinterestWhatsApp
    5
    (1222)

    Dorixina Relax, containing lysine cloxinate, functions as a non-steroidal anti-inflammatory (NSAI) medication primarily targeting pain relief. Its mechanism involves the inhibition of prostaglandin synthesis, particularly targeting the enzyme responsible for producing prostaglandins associated with inflammation (COX-2). Notably, it exhibits lesser activity on the kidneys (COX-1), where prostaglandins play a protective role.

    The cyclobenzaprine component alleviates localized skeletal muscle spasms without disrupting muscle function. It effectively reduces muscle spasm and diminishes somatic motor activity, influencing both the gamma and alpha motor systems at the central nervous system level.

    Key Facts

    1. Dorixina Relax is used for muscle pain relief: It combines cyclobenzaprine (a muscle relaxant) and other components to treat muscle spasms and related discomfort.
    2. It is typically prescribed for short-term use: Dorixina Relax is often recommended for acute conditions rather than chronic pain management.
    3. Common side effects include drowsiness and dry mouth: Users should avoid activities that require alertness, like driving, until they know how the medication affects them.

    4. It should not be mixed with alcohol or certain medications: Combining it with central nervous system depressants can increase the risk of adverse effects.

    5. Dosage should follow medical guidance: Self-medication or exceeding prescribed doses may lead to serious health risks, including overdose.

    6. Not recommended for some health conditions: People with liver issues, heart rhythm disorders, or glaucoma should consult a doctor before use.

    Pharmacokinetics

    Lysine cloxinate is rapidly absorbed, reaching peak plasma levels approximately 40-60 minutes after administration. Its bioavailability is around 56%, although there may be some individual variability. In humans, the plasma half-life of lysine cloxinate is approximately 1.75±0.10 hours (mean ± SD). Metabolites of lysine cloxinate are mainly excreted in urine, accounting for about 60% of elimination, while its concentration in milk is around 7-10% of plasma levels.

    Cyclobenzaprine is readily absorbed and highly bound to plasma proteins once in circulation. Primarily metabolized in the liver, it is predominantly excreted through the kidneys. Its elimination is relatively slow, with an effective half-life ranging from 1 to 3 days.

    Indications

    Dorixina Relax is recommended for the management of musculoskeletal pain, particularly when accompanied by muscle spasms.

    Read Also:Addressing 6 Common Misconceptions About Medical Marijuana Safety

    Contraindications

    Dorixina Relax should not be used in individuals with known hypersensitivity to Lysine clonixinate or Cyclobenzaprine, active peptic ulcer or gastroduodenal hemorrhage, pregnancy, or in children and adolescents under 15 years of age. It is also contraindicated in patients with a history of bronchospasms, nasal polyps, angioedema, or urticaria caused by the administration of acetylsalicylic acid (aspirin) or other NSAIDs.

    Due to the Cyclobenzaprine component, Dorixina Relax is contraindicated during coadministration with monoamine oxidase inhibitors (MAOIs) or within 2 weeks after their discontinuation. Additionally, it should be avoided in individuals with recent acute myocardial infarction, heart failure, arrhythmia, heart block, conduction disturbances, or hyperthyroidism.

    Pros and Cons of dorixina

    Pros of Dorixina Relax:

    • Effective Pain Relief
    • Dual Mechanism of Action
    • Rapid Absorption

    Cons of Dorixina Relax:

    • Potential Adverse Effects
    • Contraindications and Precautions
    • Interaction Risks

    Differences Between dorixina and flanax

    Dorixina:

    Works by inhibiting prostaglandin synthesis, which reduces pain and inflammation. Cyclobenzaprine, the muscle relaxant component, acts centrally on the nervous system to alleviate muscle spasms.

    Flanax:

    Naproxen sodium also inhibits prostaglandin synthesis, providing pain relief and reducing inflammation.

    Alternative to dorixina

    Muscle Relaxants:

    Alternative muscle relaxants to cyclobenzaprine in Dorixina include methocarbamol, tizanidine, baclofen, and metaxalone. These medications work by relaxing muscles and reducing muscle spasms.

    Precautions

    If allergic skin and/or mucosal reactions or symptoms of peptic ulcer or gastrointestinal hemorrhage occur, discontinue treatment with Dorixina Relax. The Cyclobenzaprine component may amplify the depressant effects of alcohol, barbiturates, or other CNS depressants. Caution is advised when administering to patients with a history of digestive diseases such as gastroduodenal peptic ulcer or gastritis and in patients treated with anticoagulants.

    Although no cases have been reported with the administration of Lysine Clonixinate, NSAIDs inhibit the synthesis of prostaglandins, which play a supportive role in maintaining renal perfusion. In patients with impaired renal blood flow, NSAID administration may precipitate renal decompensation, usually reversible upon discontinuation of the product. Patients at greatest risk include those who are dehydrated, have congestive heart failure, hepatic cirrhosis, nephrotic syndrome, or other renal diseases, as well as those taking diuretics or who have undergone major surgeries resulting in hypovolemia. In such patients, diuresis volume and renal function should be monitored before initiating therapy. While not commonly observed during treatment with Lysine clonixinate, NSAID administration may increase transaminase plasma levels or other liver parameters, though in most cases, these elevations are small and transient.

    Cyclobenzaprine, chemically related to tricyclic antidepressants and parasympatholytic drugs, should be used cautiously in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure (IOP), and in those taking anticholinergic medication.

    Pediatric use of Cyclobenzaprine is contraindicated as no clinical studies are available for children and adolescents under 15 years of age.

    In geriatric patients, like with other anti-inflammatories, Dorixina Relax should be administered with caution due to potential impairment of cardiac, hepatic, or renal functions.

    Drug interactions

    Other NSAIDs, including high doses of acetylsalicylic acid, increase the risk of gastroduodenal ulcers and hemorrhages due to their synergistic action.

    Oral anticoagulants, ticlopidine, heparin (systemic administration), and thrombolytics pose a major risk of hemorrhages when used concurrently with Dorixina Relax. If simultaneous administration is unavoidable, strict monitoring of blood coagulation is necessary, with adjustments made to the dosage of medications affecting coagulation parameters accordingly.

    Lithium levels are typically increased by NSAIDs, so close monitoring of lithium plasma levels is necessary when starting, modifying, or discontinuing treatment with Dorixina Relax.

    Concomitant use of methotrexate and NSAIDs may heighten the hematological toxicity of methotrexate. In such cases, rigorous hematological monitoring is essential.

    In patients receiving diuretics, the potential risk of acute renal failure is elevated with NSAID treatment, particularly in cases of dehydration. If Lysine clonixinate and diuretics are coadministered, patients must be adequately hydrated and their renal function monitored before initiating treatment.

    During concomitant therapy with antihypertensive agents and NSAIDs, a decrease in antihypertensive effect has been reported due to the inhibition of vasodilating prostaglandins.

    The Cyclobenzaprine component may trigger hyperpyretic crises and convulsions with a fatal outcome when interacting with MAO inhibitors. Additionally, when coadministered with guanethidine and similar compounds, it may theoretically block their antihypertensive action.

    Side effects

    At therapeutic doses, Dorixina Relax is generally well tolerated. However, in rare cases, especially in sensitive individuals, it may lead to nausea, vomiting, gastritis, and somnolence.

    The combination with Cyclobenzaprine may result in somnolence, dry mouth, and dizziness.

    Less frequently, occurring in 1-3% of cases, adverse effects may include asthenia, constipation, dyspepsia, unpleasant taste, blurred vision, headache, and nervousness.

    Adverse events reported with an incidence of less than 1% include malaise; tachycardia, arrhythmia, hypotension, palpitation; anorexia, vomiting, diarrhea, abdominal pain, gastritis, thirst, flatulence, and abnormal liver function.

    On very rare occasions, occurrences such as hepatitis and cholestasis; anaphylaxis, angioedema, pruritus, facial edema or edema of the tongue, urticaria, rash; ataxia, vertigo, dysarthria, tremor, hypertonia, muscle spasms, convulsions, disorientation, insomnia, depressed mood, anxiety, agitation, abnormal thinking and dreaming, excitement, paresthesia, diplopia; sweating; ageusia, tinnitus, and urinary frequency or retention have been reported.

    Conclusion

    Dorixina Relax is a medication generally well-tolerated at therapeutic doses, although rare adverse effects may occur, particularly in sensitive individuals. Its combination with Cyclobenzaprine can lead to additional side effects such as somnolence, dry mouth, and dizziness. While most adverse reactions are minor and resolve spontaneously, healthcare providers should be vigilant for more serious reactions, albeit rare. As with any medication, the benefits of Dorixina Relax should be weighed against the potential risks, and patients should be monitored closely for any signs of adverse effects during treatment.

    References

    1. Drugs.com. “Cyclobenzaprine: Uses, Dosage & Side Effects.” drugs.com.
      https://www.drugs.com/cyclobenzaprine.html

    2. MedlinePlus. “Muscle Relaxants.” medlineplus.gov.
      https://medlineplus.gov/musclerelaxants.html

    3. Mayo Clinic. “Cyclobenzaprine Oral Route.” mayoclinic.org.
      https://www.mayoclinic.org/drugs-supplements/cyclobenzaprine-oral-route

    How useful was this post?

    Click on a star to rate it!

    Average rating 5 / 5. Vote count: 1222

    AD

    No votes so far! Be the first to rate this post.

    As you found this post useful...

    Follow us on social media!

    We are sorry that this post was not useful for you!

    Let us improve this post!

    Tell us how we can improve this post?

    Wisdom Bassey

    My name is Wisdom Bassey, I’m a blog content writer and graphic designer who provides support and services for brands and different companies. I’m young and versatile, A tech enthusiast. I carry out deep research on every topic I choose to write about. You can reach me through my social media handles, I’m always available and ready to connect.

    Share this post
    FacebookXRedditPinterestWhatsApp

    Related posts:

    1. Health Screening: A way of finding health issues in early stage
    2. Essential First Aid Techniques Mastery
    3. active ingredient for benadryl
    4. Mental Health Guide: Tips for Choosing the Best Mental Health Counselor
    Is Dorixina a painkiller? What are the ingredients in Dorixina? What is Dorixina lysine Clonixinate used for? What is orphenadrine in English?
    Previous ArticleShopping Addiction: Signs, Effects, and How to Regain Control
    Next Article 10 Effective Ways to Improve Testosterone Levels in Your Body
    Wisdom Bassey
    • Facebook

    My name is Wisdom Bassey, I'm a blog content writer and graphic designer who provides support and services for brands and different companies. I'm young and versatile, A tech enthusiast. I carry out deep research on every topic I choose to write about. You can reach me through my social media handles, I'm always available and ready to connect.

    Related Posts

    Protein Intake

    10 Important Things to Know Before Increasing Your Protein Intake

    August 19, 2025

    The Psychology of Happiness: How Genetics, Environment, and Relationships Shape Well-Being

    August 19, 2025

    A Guide to Telemedicine Services

    August 18, 2025
    Leave A Reply

    You must be logged in to post a comment.

    Popular Posts
    6 Foods That Will Make You Taste Sweeter Down There

    6 Foods That Will Make You Taste Sweeter Down There

    Dental Instruments And Their Uses

    Why Take Flomax At Bedtime? (Explained)

    wellbutrin-zoloft

    What Are The Benefits Of Combining Wellbutrin And Zoloft? (Detailed Guide)

    Categories
    About
    Healthsoothe provide you with real evidence-based, authoritative health care information, Credible facts, experiences, and expert opinions with citations to reputable references.
    Contact Us
    For more queries and news contact us on this Email: contact@healthsoothe.com, Call Me At: +44 7700 306246,
    Caregivers Healthy Aging

    Meditation for Healthcare Professionals: Benefits, Techniques & Addiction Recovery

    Top Senior Health Conditions That Require a Professional Caregiver

    How Long Should You Wait After Using Suppositories? A Clear Guide

    Health Calculator

    Standards Growth Calculator: Track Healthy Growth for Men, Women, and Children

    BMI Calculation: Spatz Benefits

    Circumference Body fat calculator

    Oral care

    Top 6 Oral Health Resolutions for 2025 – Dentist-Approved Tips

    Understanding Teeth Overbite: Causes, Types, Symptoms, and Treatment Options

    Professional Teeth Whitening: Benefits, Costs, Risks, and Aftercare Guide

    Healthy Recipes

    Easy Snickerdoodle Cookies Recipe – Soft, Chewy & Cinnamon-Sugar Perfect

    Key Lime Cookies | The Best Easy Family Recipe for Making Soft & Fluffy Key Lime Cookies

    Fudgy Matcha Brownies Recipe | Green Tea Blondie Bars

    FacebookX (Twitter)InstagramPinterest
    • HealthSoothe Media Kit
    • Privacy & Affiliate Disclosure
    • Terms & Conditions
    • Residents of California Right
    • Our Editorial Team
    • Healthsoothe Newsletter
    • Contact us: Message Healthsoothe Today
    • Navigating Our healthsoothe.com Sitemap: Easy Access
    • Opt-out preferences
    © 2025 Healthsoothe. Designed by Healthsoothe.

    Type above and press Enter to search. Press Esc to cancel.

    Manage Consent
    To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
    FunctionalAlways active
    The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
    Preferences
    The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
    Statistics
    The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
    Marketing
    The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
    Manage optionsManage servicesManage {vendor_count} vendorsRead more about these purposes
    View preferences
    {title}{title}{title}
    Ad Blocker Enabled!
    Ad Blocker Enabled!
    Our website is made possible by displaying online advertisements to our visitors. Please support us by disabling your Ad Blocker and Reload the Page.