Losartan is prescribed for managing hypertension (high blood pressure) and safeguarding the kidneys against diabetes-related damage. Additionally, it aids in reducing the likelihood of strokes in individuals with high blood pressure and an enlarged heart. By reducing high blood pressure, it plays a role in preventing strokes, heart attacks, and kidney complications. Losartan falls under the category of medications known as angiotensin receptor blockers (ARBs), operating by relaxing blood vessels to facilitate smoother blood flow.


Tramadol is a medication used to alleviate intense pain. It is recommended when other pain-relieving drugs have proven ineffective or are not well tolerated. Tramadol functions by inhibiting pain signals in the brain and falls under the category of opioids.

This medication might have additional uses; if you have any inquiries, consult your healthcare provider or pharmacist.

Frequently known by the brand name Ultram.

How should I use this medication?

  • Ingest this medicine orally along with a full glass of water. Adhere to the instructions provided on the prescription label. It can be taken with or without food, and if it causes stomach discomfort, consume it with food. Refrain from taking the medication more frequently than instructed.
  • Your pharmacist will furnish you with a special MedGuide each time you receive a prescription or a refill. Make sure to carefully peruse this information on every occasion.
  • Discuss with your healthcare team about the administration of this medication in children, as extra caution may be necessary.
  • In the event of an overdose, promptly contact a poison control center or an emergency room if you suspect that you have consumed an excessive amount of this medicine.
  • Remember, this medication is exclusively for your use. Do not distribute this medicine to others.

Read Also: cimetidine drugs

Pros and Cons of losartan and tramadol



  • Blood Pressure Management
  • Kidney Protection
  • Heart Health


  • Side Effects
  • Potential for Interaction
  • Monitoring



  • Pain Relief
  • Versatility
  • Lower Risk of Addiction


  • Side Effects
  • Potential for Abuse
  • Serotonin Syndrome Risk

Differences Between losartan and tramadol


It is an angiotensin II receptor blocker (ARB) used primarily to treat high blood pressure (hypertension). It helps relax blood vessels, thus lowering blood pressure and improving blood flow.


It is an opioid pain medication used to relieve moderate to moderately severe pain. Tramadol works by altering the way the brain perceives and responds to pain signals.

Alternative to losartan and tramadol

Alternatives to Losartan

ACE Inhibitors:

Angiotensin-converting enzyme (ACE) inhibitors like lisinopril, enalapril, or ramipril are another class of medications used for hypertension. They work by inhibiting the production of angiotensin II.

Alternatives to Tramadol

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):

Drugs like ibuprofen, naproxen, or aspirin are NSAIDs commonly used for pain relief, especially for conditions like osteoarthritis or musculoskeletal pain.

Interactions between your drugs


There are 317 drugs that have been identified to interact with losartan.

Losartan belongs to the drug class known as angiotensin receptor blockers. It is used to manage the following conditions:

  • Alport Syndrome (off-label use)
  • Diabetic Kidney Disease
  • High Blood Pressure


There are 662 drugs known to have interactions with Tramadol Hydrochloride ER.

Tramadol Hydrochloride ER falls into the drug class of Opioids (narcotic analgesics). It is prescribed to address the following conditions:

  • Back Pain
  • Pain

Drug and food interactions

losartan food

Generally, it is advised to avoid a moderate-to-high intake of potassium in the diet, particularly from sources like salt substitutes, as this can increase the risk of hyperkalemia in individuals using angiotensin II receptor blockers (ARBs). ARBs can contribute to hyperkalemia by inhibiting the secretion of aldosterone induced by angiotensin II. Patients with conditions such as diabetes, heart failure, dehydration, or renal insufficiency are at higher risk of developing hyperkalemia.

To manage this risk, patients should receive dietary counseling and should avoid using potassium-containing salt substitutes or over-the-counter potassium supplements without consulting their physician. Regular monitoring of serum potassium levels is recommended if salt substitutes are used. Patients should also be aware of symptoms of hyperkalemia such as weakness, irregular heartbeat, confusion, tingling in the extremities, or feelings of heaviness in the legs and should seek medical attention if these symptoms occur.

Regarding interactions with grapefruit juice, it may slightly reduce and delay the conversion of losartan to its active metabolite, E3174. This effect is believed to occur due to the inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds in grapefruits. However, the clinical significance of this interaction is not well understood, and the impact can vary significantly among individuals.

Patients who regularly consume grapefruits or grapefruit juice should be monitored for any changes in the effectiveness of losartan. If an interaction is suspected, it’s advisable to avoid grapefruits and grapefruit juice. Orange juice, on the other hand, is not expected to have a similar interaction with losartan.

tramadol food

It is generally recommended to avoid alcohol while using CNS-active agents, as alcohol can enhance some of the pharmacological effects of these medications. Combining alcohol with CNS-active agents can lead to increased central nervous system depression and may impair judgment, thinking, and psychomotor skills.

To manage this interaction, patients taking CNS-active agents should be informed about the potential risks of combining them with alcohol and advised to either avoid alcohol entirely or limit its consumption. Patients should also be counseled, especially those engaging in activities requiring full mental alertness and motor coordination, to be cautious until they understand how these agents affect them. If patients experience excessive or prolonged CNS effects that interfere with their daily activities, they should promptly inform their physician.


The interaction between losartan and tramadol involves potential pharmacodynamic effects due to their distinct mechanisms of action. Losartan is an angiotensin II receptor blocker (ARB) primarily used to manage hypertension and certain kidney conditions, while tramadol is an opioid analgesic prescribed for pain relief.

When taken together, there isn’t a direct pharmacokinetic interaction reported between losartan and tramadol. However, caution is advised as both medications can cause central nervous system (CNS) depression. This means that combining them may lead to additive effects on CNS function, potentially resulting in increased drowsiness, sedation, and impaired cognitive or motor skills.

Therefore, patients using both losartan and tramadol should be closely monitored for signs of CNS depression, especially when starting or adjusting dosages. Healthcare providers may consider adjusting medication doses or providing alternative pain management strategies to minimize the risk of adverse effects.

In conclusion, while there isn’t a direct pharmacokinetic interaction between losartan and tramadol, their combination can lead to additive CNS depressant effects. Close monitoring and appropriate dose adjustments are essential to ensure patient safety and optimize therapeutic outcomes.

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The information presented on this website is not intended as specific medical advice and is not a substitute for professional treatment or diagnosis. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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