Overdose of amitriptyline might be associated with irreversible brain damage.
Does amitriptyline mess with your brain?
Amitriptyline is a strong anticholinergic medication. That means it interferes with a crucial brain chemical called acetylcholine. A study of more than 300,000 people found that those who take anticholinergic drugs like the antidepressant amitriptyline are more likely to develop dementia.
Why should you avoid amitriptyline?
Taking too much amitriptyline can cause serious side effects such as a change in your heartbeat, seizures or fits.
Why is amitriptyline a high risk medication?
Risk of heart problems, heart attack, or stroke. It's possible for amitriptyline to affect your heart rhythm and cause a fast or irregular heartbeat. In addition, some people taking medications like amitriptyline have had a heart attack or stroke during treatment.
What can I take to replace amitriptyline?
If side effects are a problem, there are other similar drugs (for example, nortriptyline, imipramine, and now duloxetine) that are worth trying as they are nearly as effective, and often have fewer side effects.
How can I get off amitriptyline?
In general, wean gradually by 25% of the daily dose every 1-4 weeks. If the reason for de-prescribing is due to serious adverse effects, consider weaning faster. Substitution with other sedative medicines is not recommended as the same adverse effects and outcomes may occur.
Do I need to wean off 10mg amitriptyline?
Is a gradual process. Your doctor may prescribed a smaller dose over time to minimize the risk of side effects of the drug.
Can 10mg amitriptyline be cut in half?
Yes. Has directed buy your doctor. They may do this to minimize the risk of side-effects.
Who shouldn't take amitriptyline?
Talk to your doctor about the risks and benefits of taking this medication if you are 65 years of age or older. Older adults should not usually take amitriptyline because it is not as safe or effective as other medication(s) that can be used to treat the same condition.