Fluoxetine is a medication that requires a prescription and is offered in various forms such as capsules, delayed-release capsules, tablets, and solutions, all of which are ingested orally. (Delayed-release capsules are designed to be absorbed into the body at a slower rate.)

The oral capsule form of fluoxetine is marketed under the brand name Prozac, but it is also available in a generic version, which is typically more cost-effective compared to branded versions. However, generic versions may not always be accessible in every strength or form as the branded ones.

Fluoxetine oral capsules may be utilized in combination therapy, necessitating concurrent use with other medications. Specifically, for managing depressive episodes associated with bipolar I disorder and treatment-resistant depression, this medication must be administered alongside olanzapine.

How to use Fluoxetine

Before using fluoxetine, read the Medication Guide from your pharmacist and review it each time you refill your prescription. If you have any questions, consult your doctor or pharmacist.

Take this medication orally as instructed by your doctor, typically once a week with or without food. Swallow the capsule whole without crushing or chewing it. Begin taking this medication 7 days after your last daily dose of fluoxetine.

The dosage depends on your medical condition and how you respond to treatment. Take the medication regularly to receive its full benefits. To help remember, take it on the same day every week and mark it on a calendar.

Continue taking this medication even if you feel better. Do not stop without consulting your doctor first, as certain conditions may worsen if the drug is suddenly stopped. Your doctor may need to reduce your dose gradually.

Inform your doctor if your condition doesn’t improve or worsens.


Antidepressants are prescribed to address various conditions, such as depression and other mental or mood disorders. These medications can be effective in preventing suicidal thoughts or attempts and offer other significant benefits. However, research indicates that a small percentage of individuals, particularly those under 25, may experience worsening depression, mental or mood symptoms, or thoughts of suicide or attempts while taking antidepressants for any reason. It’s crucial to discuss the potential risks and benefits of antidepressant use with your doctor, especially for individuals under 25, even if the treatment isn’t specifically for a mental or mood disorder.

Notify your doctor immediately if you observe any deterioration in depression or other psychiatric conditions, unusual changes in behavior (including potential suicidal thoughts or attempts), or alterations in mental or mood states (such as increased anxiety, panic attacks, difficulty sleeping, irritability, hostility or anger, impulsive behaviors, severe restlessness, or very rapid speech). Stay vigilant for these symptoms particularly when starting a new antidepressant or adjusting the dosage.


Prednisone is utilized for addressing a range of medical conditions, including arthritis, blood disorders, respiratory issues, severe allergies, skin ailments, cancer, eye conditions, and immune system disorders. It falls under the category of drugs called corticosteroids, which work by diminishing the immune system’s reaction to different illnesses, thereby alleviating symptoms like inflammation and allergic responses.

How to use prednisone

Take this medicine orally with food or milk to avoid stomach discomfort, following your doctor’s instructions. If you’re using the tablet form, use a full glass of water unless directed otherwise. When using the liquid form, measure the dose accurately with a special measuring device, not a household spoon. If prescribed once daily, take it before 9 A.M.

Follow your doctor’s directions precisely regarding dosage and schedule. The treatment duration depends on your condition and response. Use a calendar to track doses if needed, especially for non-daily schedules.

Do not discontinue the medication without consulting your doctor, as sudden cessation may worsen certain conditions. You may experience symptoms like weakness, weight loss, nausea, muscle pain, headache, tiredness, or dizziness when stopping; your doctor may taper the dose gradually to prevent such effects. Inform your doctor promptly about any new or worsening symptoms.

Keep your doctor updated about your condition’s progress.

Read Also: Discount Drug Card: Saving on Prescriptions

Pros and Cons of fluoxetine and prednisone

Fluoxetine (Prozac):


  • Effective for Depression
  • Well-Tolerated
  • Fewer Side Effects
  • Approved for Children


  • Side Effects
  • Withdrawal Symptoms
  • Interactions
  • Activation



  • Anti-inflammatory
  • Quick Relief
  • Wide Range of Uses
  • Short-Term Use


  • Side Effects
  • Withdrawal Symptoms
  • Suppression of Immune System
  • Bone Health

Differences Between fluoxetine and prednisone


 It is primarily used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, bulimia nervosa, and premenstrual dysphoric disorder (PMDD).


Prednisone is used to reduce inflammation and suppress the immune system in conditions such as rheumatoid arthritis, asthma exacerbations, allergic reactions, inflammatory bowel disease, and certain skin disorders.

Alternative to fluoxetine and prednisone

Alternatives to fluoxetine (antidepressant):

Tricyclic antidepressants (TCAs): 

While not commonly used as a first-line treatment, TCAs like amitriptyline or nortriptyline may be considered in certain cases where other antidepressants have been ineffective.

Alternatives to prednisone (corticosteroid):

Non-steroidal anti-inflammatory drugs (NSAIDs): 

For certain inflammatory conditions, NSAIDs like ibuprofen, naproxen, or celecoxib may be considered.

Interactions between your drugs


There are 667 drugs known to have interactions with Prozac.

Prozac belongs to the drug class selective serotonin reuptake inhibitors (SSRIs).

It is used to treat the following conditions:

  • Anxiety and Stress
  • Bulimia
  • Depression
  • Major Depressive Disorder
  • Obsessive Compulsive Disorder
  • Panic Disorder
  • Postpartum Depression
  • Premenstrual Dysphoric Disorder
  • Schizoaffective Disorder


There are 585 drugs known to interact with Sterapred.

Sterapred falls under the drug class glucocorticoids.

It is used to treat the following conditions:

  • Acute Lymphocytic Leukemia
  • Adrenocortical Insufficiency
  • Adrenogenital Syndrome
  • Allergic Reactions
  • Allergic Rhinitis
  • Ankylosing Spondylitis
  • Aspiration Pneumonia
  • Asthma
  • Atopic Dermatitis
  • Autoimmune Hemolytic Anemia
  • Berylliosis
  • Bullous Pemphigoid
  • Bursitis
  • Chorioretinitis
  • Cluster Headaches
  • Cogan’s Syndrome
  • Conjunctivitis, Allergic
  • Corneal Ulcer
  • Dermatitis Herpetiformis
  • Dermatomyositis
  • Eczema
  • Epicondylitis, Tennis Elbow
  • Erythroblastopenia
  • Fibromyalgia
  • Gouty Arthritis
  • Graft-versus-host disease
  • Herpes Zoster
  • Herpes Zoster Iridocyclitis
  • Hypercalcemia of Malignancy
  • Immune Thrombocytopenia
  • Immunosuppression
  • Inflammatory Bowel Disease
  • Inflammatory Conditions
  • Iridocyclitis
  • Iritis
  • Juvenile Rheumatoid Arthritis
  • Keratitis
  • Leukemia
  • Lichen Planopilaris
  • Lichen Planus
  • Lichen Sclerosus
  • Loeffler’s Syndrome
  • Lupus
  • Lymphoma
  • Mixed Connective Tissue Disease
  • Multiple Sclerosis
  • Mycosis Fungoides
  • Nephrotic Syndrome
  • Neurosarcoidosis
  • Optic Neuritis
  • Osteoarthritis
  • Pemphigoid
  • Pharyngitis
  • Polymyositis/Dermatomyositis
  • Psoriasis
  • Psoriatic Arthritis
  • Ramsay Hunt Syndrome
  • Rheumatoid Arthritis
  • Sarcoidosis
  • Scleroderma
  • Seborrheic Dermatitis
  • Sinusitis
  • Skin Rash
  • Synovitis
  • Systemic Sclerosis
  • Thrombocytopenia
  • Toxic Epidermal Necrolysis
  • Tuberculosis, Extrapulmonary
  • Tuberculous Meningitis
  • Uveitis, Posterior

Drug and food interactions

fluoxetine  food

It’s typically best to steer clear of alcohol when taking CNS-active medications, as alcohol can intensify some of the drug’s effects. Combining them can lead to increased central nervous system depression and may impair cognitive functions, judgment, and motor skills.

Patients who are prescribed CNS-active medications should be informed about this interaction and encouraged to either avoid alcohol or use it sparingly. Those who are able to move around should be advised against engaging in activities that require full mental alertness and motor coordination until they understand how these drugs affect them. If patients experience prolonged or severe central nervous system effects that disrupt their daily routines, they should inform their doctor promptly.


The interaction between fluoxetine and prednisone can have significant implications, particularly in terms of their effects on the central nervous system (CNS). Fluoxetine, as a selective serotonin reuptake inhibitor (SSRI), can interact with prednisone, a corticosteroid, resulting in potentially additive CNS effects such as central nervous system depression and impaired cognitive function. Patients should be cautious when using these medications together and should follow medical advice regarding their usage to minimize any adverse effects. It is crucial for healthcare providers to educate patients about the potential interaction between fluoxetine and prednisone and to monitor them closely for any signs of CNS-related issues.

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The information presented on this website is not intended as specific medical advice and is not a substitute for professional treatment or diagnosis. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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